Hemodynamic stabilizing effects of L-carnitine in chronic hemodialysis patients.
نویسندگان
چکیده
BACKGROUND The effects of L-carnitine on the hemodynamic state of chronic hemodialysis patients have been debated. In order to clarify the effect of administered L-carnitine on cardiac function and hypotensive episodes during the hemodialysis procedure, a randomized double-blind placebo-controlled study was performed for 3 months. METHODS AND RESULTS TWENTY STABLE OUTPATIENTS UNDERGOING HEMODIALYSIS TREATMENT WERE DIVIDED INTO TWO GROUPS: controls (placebo) and treated patients (L-carnitine 900 mg p.o. daily). After 3 months, cardiac function was reevaluated by echocardiography, and hypotensive episodes during hemodialysis were assessed. Free and acyl carnitine levels increased significantly from 22.3 ± 7.1 to 140.3 ± 57.5 μmol/l and from 15.8 ± 2.8 to 94.8 ± 50.4 μmol/l, respectively, in the treated group. The ejection fraction significantly increased from 61.8 ± 16.0 to 64.4 ± 13.8% (p < 0.05) in the treated group. However, there was no difference in other echocardiographic parameters between the two groups. Hypotensive episodes significantly decreased from 4.0 ± 1.7 to 1.3 ± 0.9 times per month (p < 0.05), although patients' body weight did not change significantly. CONCLUSIONS Beneficial effects of L-carnitine on the hemodynamic state of chronic hemodialysis patients were observed. L-Carnitine supplementation might be considered especially for chronic hemodialysis patients with unstable hemodynamic conditions.
منابع مشابه
An Evaluation of the Effects of Oral Carnitine in Decreasing Complications of Chronic Hemodialysis at Fatemieh Hospital in Semnan
Tamadon MR1, Toussy J2, Soleimani AR3, Moghimi J1, Malek F1, Moradi A4, Shahvarani A5, Tavasoli M5 1. Assistant Professor, Department of Internal, Digestion and Hepatology Research Center, Semnan University of Medical Sciences 2. Statistics Counselor, Digestion and Hepatology Research Center, Semnan University of Medical Sciences 3. Assistant Professor, Department of Internal, Kashaan Universit...
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ورودعنوان ژورنال:
- Cardiorenal medicine
دوره 3 3 شماره
صفحات -
تاریخ انتشار 2013